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Active Clinical Trials

MPR-1

Active NCT:
01793805
Allegheny General Hospital
Allegheny General Hospital

Forbes Hospital
Forbes Hospital

West Penn Hospital
West Penn Hospital

Sponsor: 
NSABP Foundation, Inc.
Contact: 

For more information, please contact Luann Healy by telephone at 412-359-8420 or email at Luann.Healy@ahn.org or Julie Russo by telephone at 412-359-6851 or email Julie.Russo@ahn.org.

MPR-1: Patient Registry and Biospecimen Profiling Repository NSABP Patient Registry and Biospecimen Profiling Repository

Purpose: 

This is a study to collect and analyze tissue specimens from metastatic colorectal cancer (mCRC) patients for the development of a molecularly profiled tissue repository for the primary purpose of maintaining a patient registry for future clinical trials based on the molecular profile of the tumors. The main purpose of testing these tissue specimens is to identify genetic alterations or biomarkers associated with colorectal cancer such that if new agent(s) become available, particularly those that target these genetic alterations/biomarkers, participants may be offered the opportunity to take part in a National Surgical Adjuvant Breast and Bowel Project (NSABP) treatment protocol

Ages Eligible for Study: 18 Years and older
Genders Eligible for Study: Both
Accepts Healthy Volunteers: No
Sampling Method: Non-Probability Sample
Study Population: Metastatic colorectal cancer patients.

Inclusion Criteria:

  • The patient must have a diagnosis of metastatic colorectal adenocarcinoma.
  • Representative formalin-fixed paraffin-embedded (FFPE) tissue blocks from the primary colorectal tumor surgery with corresponding pathology report must be available for release by the local pathology department (an adequate amount of tumor tissue is required for analysis). If available for release, a separate FFPE tissue block from an uninvolved margin of colorectal resection (normal tissue) is also requested.
  • The patient must have a life-expectancy of greater than or equal to 6 months.

Exclusion Criteria:

  • History of non-CRC malignancy unless the patient is considered by the physician to be disease-free and at low risk for recurrence.
  • Known comorbid medical conditions that would preclude investigational treatment (e.g., active hepatitis B or C; symptomatic cardiac disease; renal insufficiency; bone marrow impairment).
  • Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude investigational treatment.
  • Colonoscopy biopsies or diagnostic core biopsy procedures without surgery or resection.