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Research

Research

Fellows are introduced within the curriculum to research design, statistics, and study interpretations, as well as critical review of literature to acquire skills that foster lifelong learning. Fellows participate in the recruitment and screening of patients for enrollment into clinical trials in the Division of Rheumatology.

Physicians in training, with guidance from faculty members of the Division of Rheumatology, have contributed to the writing of manuscripts and publications in peer reviewed journals and have participated in poster presentations at national conferences.

Selected Publications:

Peer-Reviewed Journal Articles

M Y Choi, A E Clarke, Y St Pierre, J G Hanly, M B Urowitz, J Romero-Diaz, C Gordon, S-C Bae, S Bernatsky, D J Wallace, J T Merrill, D A Isenberg, A Rahman, E M Ginzler, M Petri, I N Bruce, M A Dooley, P Fortin, D D Gladman, J Sanchez-Guerrero, K Steinsson, R Ramsey-Goldman, M A Khamashta, C Aranow, G S Alarcón, S Manzi, O Nived, A A Zoma, R F van Vollenhoven, M Ramos-Casals, G Ruiz-Irastorza, S S Lim, K C Kalunian, M Inanc, D L Kamen, C A Peschken, S Jacobsen, A Askanase, J Buyon, M Mahler, M J Fritzler. The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients. Lupus. First published date: January-01-2017. 10.1177/0961203317692437

El Khoudary SR, Shields KJ, Janssen I, Budoff MJ, Everson-Rose SA, Powell LH, Matthews KA. Postmenopausal Women with Greater Paracardial Fat Have More Coronary Artery Calcification than Premenopausal Women: The SWAN Cardiovascular Fat Ancillary Study. J Am Heart Assoc. 2017 Jan 29;6(2). pii: e004545. doi: 10.1161/JAHA.116.004545.

Kassar K, Lucke M, Pu C, Tsukashita M. Fulminant Infectious Aortitis With Ascending Aortic Rupture. Ann Thorac Surg. 2017 Jan;103(1):e11-e12.

Benza RL, Lentz G, Wu C, Shields KJ, Raina A, Murali S, Passineau MJ.  In Situ Expression of bcl-2 in Pulmonary Artery Endothelial Cells Associates with Pulmonary Arterial Hypertension Relative to Heart Failure with Preserved Ejection Fraction. Pulm Circ 2016 Dec;6(4):551-556.

Beringer LT, Li S, Kallick EJ, Shields KJ, Faight EM, Cartieri F, Aballay A, Edington H, Averick S. Promoting Adipogenesis Using a Collagen VI–Heparin Sulfate Coating: Applications in Tissue Engineering for Wound Healing. Ind. Eng. Chem. Res., 2016, 55 (49), 12687–12692.

Vishwanathan S, Lucke M, Poornima IG. Triple threat in pregnancy. BMJ Case Rep. 2016 Oct 4;2016. pii: bcr2016216385. doi: 10.1136/bcr-2016-216385.

Ferraz-Amaro I, Winchester R, Gregersen PK, Reynolds RJ, Wasko MC, Oeser A, Chung CP, Stein CM, Giles JT, Bathon JM.  Coronary Artery Calcification and Rheumatoid Arthritis: Lack of Relationship to Risk Alleles for Coronary Artery Disease in the General Population. Arthritis Rheumatol. 2017 Mar;69(3):529-541.

Rao R, Yong WC, Wasko MC. Systemic light chain amyloidosis mimicking rheumatic disorders: A case report and review of literature. Case Reports in Medicine. Vol. 2016, Article ID 7649510, doi:10.1155/2016/7649510

Shields KJ, Verdelis K, Passineau MJ, Faight EM, Wu C, Chong R, Benza RL. Three Dimensional MicroCT Analysis of the Lung Vasculature and Differential Adipose Proteomics in the Sugen / Hypoxia Rat Model of PAH. Pulmonary Circulation. Pulm Circ 2016 Dec;6(4):586-596.

Lucke M, Messner W, Kim ES, Husni ME. The impact of identifying carotid plaque on addressing cardiovascular risk in psoriatic arthritis. Arthritis Res Ther. 2016 Aug 2;18:178.

Hirsch AG, Jones JB, Lerch V, Tang A, Berger AL, Clarke DN, Stewart WF. The electronic health record audit file: The patient is waiting. Journal of the American Medical Informatics Association. DOI: http://dx.doi.org/10.1093/jamia/ocw088 

Wasko MC, Dasgupta A, Sears GI, Fries JF, Ward MM. Prednisone use and risk of mortality in patients with rheumatoid arthritis: Moderation by use of disease-modifying anti-rheumatic drugs. Arthritis Care Res (Hoboken). 2016 May;68(5):706-10. 

Urowitz MB, Gladman DD, Anderson NM, Su J, Romero-Diaz J, Bae SC, Fortin PR, Sanchez-Guerrero J, Clarke A, Bernatsky S, Gordon C, Hanly JG, Wallace DJ, Isenberg D, Rahman A, Merrill J, Ginzler E, Alarcon GS, Fessler B, Petri M, Bruce IN, Khamashta M, Aranow C, Dooley M, Manzi S, Ramsey-Goldman R, Sturfelt G, Nived O, Steinsson K, Zoma A, Ruiz-Irastorza G, Lim S, Kalunian KC, Inanc M, van Vollenhoven R, Ramos-Casals M, Kamen DL, Jacobsen S, Peschken C, Askanase A, Stoll T. Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort.  Lupus Sci Med. 2016 Apr 12;3(1):e000143. doi: 10.1136/lupus-2015-000143.

Khoja S, Almeida GJ, Wasko MC, Terhorst L, Piva S. Association of Light-Intensity Physical Activity With Lower Cardiovascular Disease Risk Burden in Rheumatoid Arthritis. Arth Care Res. 2016: 68: 424–431.

Gopalarathinam R, Orlowsky E, Kesavalu R, Yelaminchili S. Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options. Case Reports in Rheumatology. vol. 2016, Article ID 6502373, doi:10.1155/2016/6502373.

Hanly JG, Su L, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Petri M, Bruce IN, Dooley MA, Fortin P, Gladman DD, Sanchez-Guerrero J, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Alarcón GS, Fessler BJ, Manzi S, Nived O, Sturfelt GK, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Sam Lim S, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Theriault C, Farewell V. A Longitudinal Analysis of Outcomes of Lupus Nephritis in an International Inception Cohort Using a Multistate Model Approach. Arthritis Rheumatol. 2016 Aug;68(8):1932-44.

Sharma TS, Joyce E, Wasko MC. Antimalarials: Are there benefits beyond mild disease? Curr Treat Options in Rheum, 2016(2): 1-12.

Sharma TS, Wasko MC, Tang X, Vedamurthy D, Yan X, Cote J, Bili A. Hydroxychloroquine Use Is Associated With Decreased Incident Cardiovascular Events in Rheumatoid Arthritis Patients. J Am Heart Assoc. 2016 Jan 4;5(1). pii: e002867.

Hanly JG, O'Keeffe AG, Su L, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Fortin P, Gladman DD, Sanchez-Guerrero J, Petri M, Bruce IN, Dooley MA, Ramsey-Goldman R, Aranow C, Alarcón GS, Fessler BJ, Steinsson K, Nived O, Sturfelt GK, Manzi S, Khamashta MA, van Vollenhoven RF, Zoma AA, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Stoll T, Inanc M, Kalunian KC, Kamen DL, Maddison P, Peschken CA, Jacobsen S, Askanase A, Theriault C, Thompson K, Farewell V. The frequency and outcome of lupus nephritis: results from an international inception cohort study. Rheumatology (Oxford). 2016 Feb;55(2):252-62.

Demirci FY, Wang X, Kelly JA, Morris DL, Barmada MM, Feingold E, Kao AH, Sivils KL, Bernatsky S, Pineau C, Clarke A, Ramsey-Goldman R, Vyse TJ, Gaffney PM, Manzi S, Kamboh MI. Identification of a New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12 in Individuals of European Ancestry. Arthritis Rheumatol. Arthritis Rheumatol. 2016 Jan;68(1):174-83.

Books, Monographs, and Chapters

Tang X, Luo Z, Gardiner JC. A Bivariate Random-Effects Copula Model for Length of Stay and Cost. In Statistical Applications from Clinical Trials and Personalized Medicine to Finance and Business Analytics: Selected Papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins (Editors Lin J, Wang B, Hu X, Chen K, Liu R). Springer, Cham, Switzerland, 2016.

Abstracts

Maan D, Bunker M, Wasko MC, Clark B. Irrelevant ANCA Negative Pauci Immune Crescentic GN in a Man with Rheumatoid Arthritis (Accepted for presentation at the National Kidney Foundation (NKF) 2017 Spring Clinical Meetings, Orlando, FL, April 2017).

Nellaiyappan M, Pappas O, Krishnamoorthy P, Tang X, Poornima I. Epidemiology and outcomes of intracavitary cardiac metastases - a review (Accepted for presentation at American Heart Association Fellow Research Day, Pittsburgh, PA, January 2017).

Liu H, Veer M, Habbach A, Jungmin L, Joyce E, Tang X, Kapetanos A. New EMR results in new anxieties - but do we need to order more STAT Labs? (Accepted for presentation at ACP Western PA Meeting, Pittsburgh, PA, November 2016).

Ferraz-Amaro I, Winchester R, Gregersen PK, Reynolds RJ, Oeser AM, Chung CP, Stein CM, Wasko MCM, Giles JT, Bathon J. Coronary Artery Calcification in Rheumatoid Arthritis Patients Is Not Characterized By an Increase in Genes Associated with Coronary Artery Disease in the General Population (Accepted for presentation at the ACR Annual Meeting, Washington, DC, November 2016).

Bernatsky S, Urowitz M, Hanly J, Clarke AE, Gordon C, Romero-Diaz J, Alarcon GS, Bae SC, Petri M, Merrill JT, Wallace DJ, Fortin PR, Gladman DD, Isenberg DA, Rahman A, Manzi S, Nived O, Sturfelt GK, Peschken C, Sánchez-Guerrero J, Ruiz-Irastorza G, Aranow C, van Vollenhoven RF, Zoma A, Steinsson K, Khamashta M, Ginzler EM, Askanase A, Kalunian KC, Dooley MA, Lim SS, Kamen DL, Jacobsen S, Ramos-Casals M, Inanc M, Labrecque J, Lee JL, Ramsey-Goldman R. Cancer in Systemic Lupus Erythematosus: Results from the Systemic Lupus International Collaborating Clinics Inception Cohort (Accepted for presentation at the ACR Annual Meeting, Washington, DC, November 2016).

Furie R, Askanase AD, Kalunian K, Massarotti E, Ramsey-Goldman R, Wallace DJ, Silverman SL, Reddy S, Chitkara P, Putterman C, Collins C, Buyon JP, Arriens C, O'Malley T, Alexander R, Barken D, Conklin J, Manzi S, Ahearn J, Weinstein A, Dervieux T. Multi-Center Validation of Platelet Bound C4d, a Biomarker for Systemic Lupus Erythematosus (Accepted for presentation at the ACR Annual Meeting, Washington, DC, November 2016).

Wallace DJ, Ramsey-Goldman R, Askanase AD, Manzi S, Ahearn J, Furie R, Weinstein A, Putterman C, Massarotti E, Collins C, Kalunian K, Arriens C, Silverman SL, Reddy S, Chitkara P, Ibarra C, Barken D, Alexander R, Conklin J, Dervieux T. Prospective Validation of a Panel of Autoantibodies in Combination with C4d-Bound Complement Activation Products for the Differential Diagnosis of Systemic Lupus Erythematosus (Accepted for presentation at the ACR Annual Meeting, Washington, DC, November 2016).

Hanly JG, Li Q, Su L, Urowitz M, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Fortin PR, Gladman D, Sanchez-Guerrero J, Petri M, Bruce IN, Dooley MA, Ramsey-Goldman R, Aranow C, Alarcon GS, Steinsson K, Sturfelt GK, Nived O, Manzi S, Khamashta M, van Vollenhoven RF, Zoma A, Ruiz-Irastorza G, Lim SS, Inanc M, Kalunian KC, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Theriault C, Farewell V, Ramos-Casals M. Risk Factors for Cerebrovascular Events in Systemic Lupus Erythematosus: Results from an International, Inception Cohort Study (Accepted for presentation at the ACR Annual Meeting, Washington, DC, November 2016).

Greco C, Chen LW, Cheng Y, McFarland C, Manzi S. Mind-Body Skills Training and Supportive Counseling for Depression in SLE: Positive Effects in a Randomized Controlled Trial (Accepted for presentation at the ACR Annual Meeting, Washington, DC, November 2016).

Hanly JG, Li Q, Su L, Urowitz M, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Fortin PR, Gladman D, Sanchez-Guerrero J, Petri M, Bruce IN, Dooley MA, Ramsey-Goldman R, Aranow C, Alarcon GS, Steinsson K, Sturfelt GK, Nived O, Manzi S, Khamashta M, van Vollenhoven RF, Zoma A, Ruiz-Irastorza G, Lim SS, Inanc M, Kalunian KC, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Theriault C, Farewell V, Ramos-Casals M. Risk Factors for Cerebrovascular Events in Systemic Lupus Erythematosus: Results from an International, Inception Cohort Study (Accepted for presentation at the ACR Annual Meeting, Washington, DC, November 2016).

Greco C, Chen LW, Cheng Y, McFarland C, Manzi S. Mind-Body Skills Training and Supportive Counseling for Depression in SLE: Positive Effects in a Randomized Controlled Trial (Accepted for presentation at the ACR Annual Meeting, Washington, DC, November 2016).

Barber M, Bruce IN, Urowitz M, Hanly JG, Su L, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Petri M, Dooley MA, Fortin PR, Gladman DD, Sanchez-Guerrero J, Steinsson K, Ramsey-Goldman R, Khamashta M, Aranow C, Alarcon GS, Fessler BJ, Manzi S, Nived O, Jönsen A, Zoma A, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Buyon JP, Theriault C, Farewell V, Clarke AE. Economic Evaluation of Damage Accrual in an International SLE Inception Cohort (Accepted for presentation at the ACR Annual Meeting, Washington, DC, November 2016).

Kimoto MA, Wasko MC, Sharma T. Adherence to American College of Rheumatology Immunization Recommendations for Rheumatoid Arthritis Patients in a Tertiary Care Health System and Opportunities to Close the Gap (Accepted for presentation at ACP Western PA Meeting, Pittsburgh, PA, November 2016, and ACR Annual Meeting, Washington, DC, November 2016).

Shirey DJ, Liu CC. Diagnostic Utility of Cellular Bound Complement Activation Proteins in Systemic Lupus Erythematosus. (Accepted for presentation at Lake Erie College of Osteopathic Medicine Interdisciplinary Research Initiative Day, Erie, PA, October 2016).

Manapuram S, Chilkulwar A, Padhi P, Pasricha G, Tang X, Monga D. Adjuvant Chemotherapy with FOLFOX in Elderly Patients (age ≥ 70 years) with Stage II or Stage III Colon Cancer: A Retrospective Study in the Community Setting. (Accepted for presentation at the Pennsylvania Society of Hematology and Oncology Annual Scientific Meeting, Harrisburg, PA, September 2016).

Pasricha G, Beg M, Beygi S, Kaplan R, Wasko MC. Peripartum Lupus Flare, CAPS, or Both: A Diagnostic and Therapeutic Challenge. (Accepted for presentation at the Pennsylvania Society of Hematology and Oncology Annual Scientific Meeting, Harrisburg, PA, September 2016).

Payne C, Wasko MC. Barriers to Adherence to 2011 Guidelines for Hydroxychloroquine Baseline Retinal Screening. (Accepted for presentation at the PA Rheumatology Society Meeting, Hershey, PA, September 2016).

Joyce E, Whisler D, Lowther H. Tumor Necrosis Factor (TNF) Blocker Administration: Compliance with Screening Guidelines prior to Initiation. (Accepted for presentation at the PA Rheumatology Society Meeting, Hershey, PA, September 2016).

Joyce E, Wasko MC. ALAmyloid case. (Accepted for presentation at the PA Rheumatology Society Meeting, Hershey, PA, September 2016).

Vishwanathan S, Poornima IG, Lucke M. Triple Threat-Pregnancy, Nephritis, and Myocarditis (Accepted for presentation at SGIM National Meeting, Hollywood, FL, May 2016; Third place winner: Outstanding Clinical Vignette Poster at AHN Resident Research Day, Pittsburgh, PA, May 2016).

Kimoto M, Lucke M. IgG4 Related Disease: A Novel Differential for Acute Lower Extremity Edema (Accepted for presentation at Clinical Congress of Rheumatology, Destin, FL, May 2016; Second place winner: Outstanding Clinical Vignette Poster at AHN Resident Research Day, Pittsburgh, PA, May 2016).

Beygi S, Denio A, Sharma TS. The Foot That Broke Both Hips: A Case of Tumor Induced Osteomalacia (First place winner: Outstanding Clinical Vignette Poster at AHN Resident Research Day, Pittsburgh, PA, May 2016).

Kimoto M, Gopalarathinam R, Theis D. Dehydration and Dysphagia as Acute Precipitants of Low-Dose Methotrexate-Mediated Toxicity. (Accepted for presentation at the 2016 Society of Hospital Medicine Annual Meeting, San Diego, CA, March 2016; Accepted for presentation at AHN Resident Research Day, Pittsburgh, PA, May 2016).

Liu H, Veer M, Habbach A, Lee J, Joyce E, Tang A, Kapetanos A. New EMR (EPIC) Implementation Results in More STAT Lab Orders. (Accepted for presentation at AHN Resident Research Day, Pittsburgh, PA, May 2016).

Joyce E, Whisler D, Gopalarathinam R, Lowther H. Tumor Necrosis Factor (TNF) Blocker Administration: Compliance with Screening Guidelines Prior to Initiation. (Accepted for presentation at AHN Resident Research Day, Pittsburgh, PA, May 2016).

Habbach A, Veer M, Lee J, Joyce E, Tang A, Kapetanos A. Improvement of the STAT Lab Turnaround Time. (Accepted for presentation at AHN Resident Research Day, Pittsburgh, PA, May 2016).

McCloskey J, Ved R, Wasko MC. Pulmonary Artery Compression from Metastatic Malignant Melanoma: A Therapeutic Conundrum. (Accepted for presentation at AHN Resident Research Day, Pittsburgh, PA, May 2016).

Liu CC, Schofield T, Manzi S, Ahearn JM. Autoantibody-mediated generation of platelet-bound C4d in Systemic Lupus Erythematosus (SLE). (Accepted for presentation at the 2016 American Association of Immunologists Annual Meeting, Seattle, WA, May 2016).

Liu CC, McCarty BE, McGeary M, Manzi S, Ahearn J. Complement-tagged basophils and eosinophils in Systemic Lupus Erythematosus (SLE). (Accepted for presentation at the 2016 American Association of Immunologists Annual Meeting, Seattle, WA, May 2016).

Gopalarathinam R, Orlowsky E, Kesavalu R, Yelaminchili S. Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options. (Accepted for presentation at the 2016 Society of General Internal Medicine Annual Meeting, Hollywood, FL, May 2016).

Gopalarathinam R, Indramohan P, Sharma T. Granulomatosis with Polyangiitis: A Storm in the Brain. (Accepted for presentation at the 2016 Society of General Internal Medicine Annual Meeting, Hollywood, FL, May 2016).

Gopalarathinam R, Vishwanathan S, Indramohan P, Kumar AM, Sharma T. Eosinophilic Granulomatosis with Polyangiitis: Not for the Lighthearted. (Accepted for presentation at the 2016 Society of General Internal Medicine Annual Meeting, Hollywood, FL, May 2016).

Gopalarathinam R, Orlowsky E, Kesavalu R, Yelaminchili S. Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options. (Accepted for presentation at the 2016 Society of General Internal Medicine Mid-Atlantic Regional Meeting, Hempstead, NY, April 2016).

Gopalarathinam R, Indramohan P, Sharma T. Granulomatosis with Polyangiitis: A Storm in the Brain. (Accepted for presentation at the 2016 Society of Hospital Medicine Annual Meeting, San Diego, CA, March 2016).

Gopalarathinam R, Vishwanathan S, Indramohan P, Kumar AM, Sharma T. Eosinophilic Granulomatosis with Polyangiitis: Not for the Lighthearted. (Accepted for presentation at the 2016 Society of Hospital Medicine Annual Meeting, San Diego, CA, March 2016).

Shields KJ, Ahearn J, Manzi S. Small Visceral Adipose Volumes and Quality Associated with Aortic and Coronary Artery Calcification in Women with SLE. (Accepted for poster presentation at the EPI/Lifestyle 2016 Scientific Sessions, Phoenix, AZ, March 2016)