Balloon Pulmonary Angioplasty (BPA)

The goal of balloon pulmonary angioplasty is to open up the narrowed or blocked pulmonary arteries in the lungs, thereby reducing the pressure in the pulmonary circulation and improving blood flow and oxygenation.

Balloon pulmonary angioplasty (BPA) is a minimally invasive catheter-based procedure designed to treat chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH is a rare and severe form of pulmonary hypertension where persistent blood clots (thrombi) in the pulmonary arteries scar and narrow the vessels, leading to dangerously high blood pressure in the lungs. This high pressure forces the right side of the heart to work much harder, eventually leading to heart failure.

Balloon pulmonary angioplasty is a very uncommon and specialized procedures since the underlying condition, chronic thromboembolic pulmonary hypertension (CTEPH), is itself rare. While acute pulmonary embolism (blood clot in the lung) is relatively common, only a small percentage (around 0.5% to 5%) of patients who survive an acute pulmonary embolism go on to develop chronic, organized clots that cause CTEPH. BPA is a technically demanding and requires significant expertise and experience. It's only performed in a limited number of highly specialized centers worldwide with dedicated CTEPH programs, like AHN.

BPA procedure: Why choose AHN?

Given the rarity of Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and highly complex nature of the balloon pulmonary angioplasty, seeking care from a dedicated and experienced center like AHN is critical. AHN is one of the few providers with a dedicated CTEPH program. Here you will be under the care of cardiologists who have performed this complex procedure numerous times and have improved patient outcomes. At AHN, we see you and your unique needs first.

What to expect for a BPA

BPA is a minimally invasive procedure that is performed in a specialized hospital setting, specifically in a cardiac catheterization lab (sometimes called an interventional cardiology suite or a hybrid operating room). These labs are equipped with advanced imaging technology (like fluoroscopy, which uses X-rays to visualize the inside of the body) and specialized tools required for these intricate procedures.

The BPA procedure is typically performed over several sessions, not just one, because many different segments of the lung arteries often need to be treated. Each session usually lasts a few hours.

Here's what you can expect prior to the procedure:

  • Preparation: This usually includes a review of the medication being taken. You will also likely need to fast before the procedure.
  • Access site preparation: The area where the catheter will be inserted (usually the groin or sometimes the neck/arm) will be cleaned and numbed with a local anesthetic.
  • Sedation: Patients will receive conscious sedationto help them relax, reduce anxiety, and minimize discomfort during the procedure. They will be drowsy but able to respond.

During the procedure:

  • Catheter insertion: A thin, flexible tube called a guide catheter is inserted into a blood vessel (typically in the groin, a large vein) and carefully threaded up into the right side of the heart and then into the pulmonary arteries within the lungs.
  • Imaging: Contrast dye is injected, and X-ray imaging (fluoroscopy) is used to visualize the pulmonary arteries and identify the narrowed or blocked areas.
  • Balloon angioplasty: Once a blocked or narrowed segment is identified, a very fine wire is advanced through the guide catheter and past the blockage. A tiny balloon catheter is then threaded over this wire to the site of the blockage. The balloon is briefly inflated to push aside the old clot material and widen the artery, then deflated and removed.
  • Repeat: This process is repeated for several blocked segments during each session. Because there are many areas that often need treatment, it's typically done in multiple separate sessions (e.g., three to six sessions spread out over weeks or months), treating different lung segments in each session.
  • Monitoring: Throughout the procedure, the patient's heart rate, blood pressure, and oxygen levels are continuously monitored.

BPA recovery

The recovery from balloon pulmonary angioplasty is a multistage process that spans from immediately after each procedure session to a longer period of gradual improvement and ongoing management.

Immediately after each BPA session, the patient is transferred to a recovery area or sometimes a specialized cardiac unit. Here, nurses closely monitor vital signs (heart rate, blood pressure, oxygen saturation), the catheter insertion site (usually in the groin), and watch for any potential complications.

Patients will typically need to lie flat for several hours (often four to six hours) after the procedure. This is crucial to prevent bleeding or bruising at the site where the catheter was inserted. Movement of the limb where the access was gained (e.g., leg if groin access) will be restricted.

Mild discomfort or bruising at the access site is common. Some patients may experience a sensation of chest tightness or mild chest pain, which is usually manageable with over-the-counter pain relievers.

For the initial sessions, or if any concerns arise, patients often stay in the hospital overnight for observation. For later, uncomplicated sessions, it might sometimes be an outpatient procedure, meaning they go home the same day.

Patients are encouraged to drink plenty of fluids to help flush the contrast dye from their system. It's common to feel tired or fatigued for a few days after each procedure. The body is working to heal and adjust.

For a few days after each session, patients are generally advised to:

  • Avoid strenuous physical activity, heavy lifting, or vigorous exercise.
  • Avoid prolonged standing or sitting, especially if groin access was used, to minimize pressure on the insertion site.
  • Keep the access site clean and dry.
  • Ensure they are resting appropriately and being patient as their body is healing. 
  • Take medication as prescribed, including blood thinners, which are critical for preventing new clot formation and are typically continued for life in CTEPH patients.

Regular follow-up with the cardiologist/pulmonologist is crucial. These appointments involve:

  • Assessing symptom improvement.
  • Performing tests like echocardiograms or right heart catheterizations to measure pulmonary artery pressures and confirm the effectiveness of the treatment.
  • Planning for subsequent BPA sessions.
  • Determining lifestyle adjustments. While BPA significantly improves the underlying condition, patients are still encouraged to maintain a heart-healthy lifestyle, including a balanced diet and regular, appropriate exercise as advised by their doctor.

BPA FAQs

A heart procedure as complex and rare as balloon pulmonary angioplasty (BPA) can bring about questions and, potentially, concerns. AHN is here to help you feel confident in your understanding of this procedure. Your AHN care team is available to help answer your specific questions and guide you through the process. But, to help familiarize you with the procedure, we’ve included some of our patients’ most frequently asked questions. Many patients use this information to guide conversations with their care team.

What is the survival rate for balloon pulmonary angioplasty?

The survival rate for balloon pulmonary angioplasty (BPA) for patients with chronic thromboembolic pulmonary hypertension (CTEPH) has significantly improved as the procedure has evolved and operator experience has grown. While specific percentages can vary depending on the study, patient population, and definition of survival (e.g., in-hospital, 30-day, one-year), contemporary studies often report very favorable outcomes.

For instance, one-year survival rates after BPA in specialized centers are frequently reported to be over 90%, and in some cohorts, even higher.* Long-term survival also demonstrates significant improvement compared to the natural history of untreated CTEPH. It's important to note that survival rates are generally highest in experienced centers with high procedural volumes and robust patient selection protocols.

What are the complications of balloon pulmonary angioplasty?

While BPA is a lifesaving procedure for many, it is not without potential complications. These can range from minor to severe and include:

  • Vascular complications: These are common and can include vessel dissection, perforation (which can lead to hemoptysis or pulmonary hemorrhage), or rupture of pulmonary arteries.
  • Respiratory Complications: Hemoptysis (coughing up blood) is relatively common and usually self-limiting, but severe pulmonary hemorrhage can occur, requiring intervention. Pleurisy and pulmonary edema can also be observed.
  • Cardiac complications: Arrhythmias, right heart failure exacerbation, or even cardiac arrest, though rare, are possible.
  • Contrast-induced nephropathy: As with any procedure involving contrast dye, there is a risk of kidney injury, especially in patients with preexisting renal impairment.
  • Radiation exposure: Patients are exposed to radiation during the procedure, though efforts are made to minimize this.
  • Access site complications: Bleeding, hematoma, or infection at the site where the catheter is inserted (usually the groin or neck).
  • Reperfusion injury: In some cases, reperfusion of previously ischemic lung tissue can lead to inflammation or transient worsening of lung function.

The incidence and severity of these complications have decreased with advancements in imaging, catheter technology, and operator expertise.

What is the success rate of balloon pulmonary angioplasty?

The success rate of BPA can be defined in several ways, often encompassing both procedural success and clinical improvement.

  • Procedural success: This refers to the ability to successfully dilate and improve blood flow in the targeted pulmonary arteries. This is generally very high in experienced hands, often exceeding 90% for individual lesions.*
  • Hemodynamic success: This is a crucial measure, indicating significant improvement in pulmonary artery pressures and pulmonary vascular resistance (PVR) after the procedure. Studies consistently show that successful BPA leads to substantial and sustained reductions in mean pulmonary artery pressure and PVR.
  • Clinical success: This is perhaps the most important measure for patients, focusing on improvements in functional capacity, symptoms (like dyspnea), and quality of life. Patients undergoing successful BPA typically experience a significant improvement in their exercise capacity (e.g., six-minute walk distance) and a reduction in their WHO Functional Class. Many studies report clinical improvement in a large majority of patients, often upwards of 80 –90% who complete a full course of BPA sessions.**

It's important to note that BPA is often performed in multiple sessions, targeting different segments of the pulmonary vasculature over time to achieve optimal results.

Contact us

If you have not been diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH) or do not have a referral for balloon pulmonary angioplasty, call (412) DOCTORS 412-362-8677 to schedule an appointment with a general cardiologist to be evaluated if this kind of procedure is needed.